Retatrutide is an injectable peptide that targets three metabolic pathways (GIP, GLP-1, and glucagon receptors) to reduce appetite, improve blood sugar control, and increase energy expenditure. It’s currently being studied for obesity and type 2 diabetes management. It is the strongest peptide in weight management found to date.

Store pens in the refrigerator (2–8°C) — but always follow the manufacturer label when available.

Retatrutide is a subcutaneous injection (or SC injection) which sends medication into the layer of fat beneath the skin, between the skin and the muscle. Typically into the abdomen, thigh, or upper arm.

Most common: nausea, vomiting, diarrhea, constipation, or decreased appetite. These usually lessen over time.

Some research report reduced appetite immediately, or within 1–2 weeks, but significant weight loss or glucose improvements tend to appear after 4–8 weeks, increasing steadily over months.